First invented by K.C. Cole in the 1940 and subsequently used by Hogkin and Huxley for the characterization of the action potential in the squid giant axon, the voltage clamp consists in an electronic feedback, which maintains the potential of the cell at a desired value and measures the amount of necessary current. A typical diagram of the voltage clamp circuit is illustrated below.

Two electrodes voltage-clamp can be performed in Xenopus oocytes and was successfully automatized in collaboration with Multichannelsystems.

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